22-P005 Mechanisms of primitive endoderm specification – From ES cells to preimplantation mouse development
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چکیده
منابع مشابه
22-P005 Mechanisms of primitive endoderm specification – From ES cells to preimplantation mouse development
Gonadotropin releasing hormone (GnRH) is a multifunctional decapeptide that possess endocrine as well as neuromodulatory roles and is present in all vertebrates. Endocrine GnRH cells play a crucial role in the establishment of the hypothalamic–pituitary– gonadal axis in many species. Recent studies have found that the prokineticin2 (pk2) and prokineticin receptor2 (pkr2) genes are involved in t...
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In amniotes, primitive endoderm (PrE) plays important roles not only for nutrient support but also as an inductive tissue required for embryo patterning. PrE is an epithelial monolayer that is visible shortly before embryo implantation and is one of the first three cell lineages produced by the embryo. We review here the molecular mechanisms that have been uncovered during the past 10 years on ...
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During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of ma...
متن کاملEndoderm specification
In this chapter I focus on the emergence of endoderm, the origin of these cells and their organization in space. I also discuss the molecular events that lead to endoderm formation and how endoderm can be molecularly defined. Although the molecular control of endoderm formation has initially been deciphered using Xenopus, Zebrafish, sea urchin and several other species many molecular switches h...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.1216